Chromosome Evil

Chromosome Evil

Released Mar 2022

Dive deep into this Lovecraft-inspired RTS survival. Assemble your team using different classes, skills, and weaponry. It's up to your squad to survive the onslaught of nightmares that are surely coming your way. Will you find the source of the darkness?

80% positive · 360 reviews
Done
All announced content has been released
High confidence
Done
All announced content has been released
High confidence

Where to buy

Steam $14.99
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Evaluation

Chromosome Evil launched on March 24, 2022 and received a series of post-launch DLC updates: DLC 1 (new weapons and customization, May 2022), DLC 2 (map editor, June 2022), DLC 3 (cheat trainer, December 2022), and DLC 4 (a "Behind the Curtain" post-mortem PDF, February 1, 2024). On February 1, 2024, the developer explicitly announced that DLC 4 was "the final DLC" and that it was "the last update on Chromosome Evil," citing exhausted funds and low sales. All four DLC items listed on the store are released with no unreleased entries remaining. The developer has since moved on to sequels and entirely new projects — Chromosome Evil 2 launched in February 2024, and on February 27, 2026, the developer announced that the Chromosome Evil Trilogy is now complete with a permanent Steam bundle. No further content for the original Chromosome Evil has been announced or suggested at any point after February 2024.
Evidence
Developer announced the Chromosome Evil Trilogy is now complete and created a permanent Steam bundle for all three games. No further content for the original game was mentioned.
news post · Feb 27, 2026 source development ending
high
Developer explicitly announced DLC 4 as the 'final DLC' and stated 'this is our last update on Chromosome Evil,' citing exhausted funds and no critical bugs remaining.
news post · Feb 1, 2024 source development ending
high

Content

4 of 4 released · no outstanding content

Media

Details

Publisher
S.C. 16 BIT NIGHTS S.R.L.
Achievements
19
Platform
Windows
Controller
—
Steam Deck
Playable
Players
Single-player

About this game

Real-time strategy gameplay mixed with Horror elements.

Squad based controls, multiple possibilities according to the way you build your team, soldiers are good killers, engineers can establish defense perimeter by building turrets, barricades or using special key points from the environment to build traps and medics can keep your team alive on a long run

During this stage, you choose which location you want to send your squad to search for supplies and information, you choose how you want to equip your survivors and what skills you want them to get stronger at, you choose your route and you decide the best course of action for the random events that will present before you.

This is not your classical zombie outbreak, no, this story is much darker inspired by Lovecraft works, an ancient evil has returned from below the earth bringing with him creatures of nightmare, abominations of unspeakable terror and if that was not enough, the dead humans are brought back to life as animated flesh to fight alongside this evil.

You are part of what remains of army forces, your brother, the one who took care of you when your parents died was also part of the army and went missing during a mission a few miles from where you are stationed with the objective to gather information about these underground holes from were these creatures are coming from. You decide to embark on one last journey of redemption to see your brother one more time.

                                                   Good luck Commander!

Last evaluated Jun 26, 2026
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