S.E.M.I. – Side Effects May Include...

S.E.M.I. – Side Effects May Include...

Released Jan 2026

S.E.M.I. is a single-player and co-op action platformer with puzzle elements. Play as patients of an unusual clinic, take experimental drugs, interfere with each other, and be ready for chaos and unpredictable side effects!

85% positive · 113 reviews
Done
All announced content has been released
Medium confidence
Done
All announced content has been released
Medium confidence

Where to buy

Steam $7.99
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Evaluation

S.E.M.I. launched into Early Access on November 20, 2025 and graduated to its full 1.0 release on January 23, 2026. The release brought substantial new content: Stage 3 with 12 unique levels, 2 puzzle levels, 1 final Crazy Room, and an expanded Diagnosis System. After launch, the developer shipped one feature patch on February 11, 2026 adding Steam Achievements and trading cards. That post ended with "What's next? We'll keep that a secret for now — stay tuned," which is a vague tease rather than a concrete announcement of named content. The previous evaluation treated this tease as evidence of planned content. Reassessing against today's date of September 24, 2026: the February 11, 2026 post is the last developer communication on record, now over 7 months ago. No roadmap, no named upcoming DLC, no unreleased DLC on the store, and no subsequent developer statement has materialized to confirm what that hint referred to. A throwaway "stay tuned" line in a patch note — with no follow-up in over 7 months — is not sufficient to sustain a content_planned signal. It is equally plausible that the tease referred to the Steam Achievements themselves, or to minor cosmetic additions that may or may not have shipped without a news post. Looking at the broader update pattern: the game had active development during its Early Access period (November–January), with patches approximately every 2–4 weeks. After the 1.0 launch, only one post-launch patch was issued (February 11, 2026), and there has been complete silence since. There is no established post-launch cadence of major content releases — only one post-launch patch exists. The game shipped with no outstanding commitments and no unreleased DLC. All three DLC items (two soundtracks and a digital artbook) are released. The developer has not announced future content in any concrete or specific way, no unreleased DLC is listed, and the silence since February 11, 2026 has extended well beyond any reasonable expectation for a game with this update history. The game was launched as a complete 1.0 product and the available evidence points to it having shipped as a finished package.
Evidence
S.E.M.I. officially left Early Access and launched as a full 1.0 release, described as 'the most complete, stable, and polished S.E.M.I. experience to date.' New content included Stage 3 with 12 levels, expanded Diagnosis System, and new enemies.
news post · Jan 23, 2026 source content shipped
high
Pre-release New Year's update outlined plans for a third run stage and expanding content — content that was subsequently delivered in the January 23, 2026 full release.
news post · Dec 24, 2025 source content shipped
medium

Content

3 of 3 released · no outstanding content

Media

Details

Publisher
Two Horn Unicorn
Achievements
9
Platform
Windows
Controller
full support
Steam Deck
Not rated
Players
Single-player · Multiplayer · Co-op

About this game

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here, you and up to 3 of your brainless loyal friends play as patients, fighting staff and other patients while stumbling into all sorts of unexpected situations. Brawls, side-effect pills, and brutal platforming will absolutely challenge your clumsy friends’ hands sense of teamwork. Expect obstacles, puzzles, deadly traps, and rooms where a single wrong move can knock out the entire squad.

Communicate in voice chat and arrange sabotage help your friends pass through rooms, get out of traps and fight with opponents! In your arsenal: close combat, physics, amazing abilities and ... imagination!

Take pills and get abilities:

  • Bipolar force is an invulnerable monster, then a helpless rag!

  • Laser astigmatism — two sights, one laser… Where will he shoot?

  • Stendhal syndrome — are you looking at a painting? Now you're hysterical and destroying everything around you!

  • Alice's syndrome is either tiny or gigantic — have time to adjust!

Madness is near! You and your friends can go crazy and start running, jumping and fighting, and your abilities will become uncontrollable. Do you want to take back control? Take the pills :)

Locations are randomly generated from rooms with changing gravity, traps, moving walls, and other "pleasant" surprises.

After a successful escape, you will receive a medical report: "The patient was stable until he started hitting the guards with a bottle. Diagnosis: Overmotivation" or something worse!

Unlock new costumes and decorations. Let each new escape be more stylish than the previous one!

Will you and your friends be able to escape... or at least not go crazy?

Welcome to the mental hospital! Here, your abilities are a lottery, and your friends can be the most dangerous opponents!

Last evaluated Sep 24, 2026
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