Genome Guardian

Genome Guardian

Released May 2024

COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!

91% positive · 782 reviews
Done
All announced content has been released
Medium confidence
Done
All announced content has been released
Medium confidence

Where to buy

Steam $4.79 $11.99 −60%
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Evaluation

Genome Guardian launched on May 7, 2024 and received a series of post-launch updates from the solo developer at Alpherior. The game grew substantially through six numbered major updates, culminating in Major Update 6: Full Spectrum on October 14, 2024, which completed the full roster of 49 turrets and 96 perks and explicitly made 100% checklist completion possible for the first time. Following that, updates shifted to feature patches and bug fixes rather than new content additions. The developer's focus then moved to two successor projects. On January 25, 2025, the developer confirmed they still had update plans for Genome Guardian but were fully focused on Cell Command (a companion game set in the same universe), which released on June 19, 2025. On November 27, 2025, the developer announced Genome Guardian 2, and on March 5, 2026, Genome Guardian 2 launched into Early Access — a separate game on a separate store page. The most recent patch for the original Genome Guardian (Update 7.0.4, July 21, 2025) was a minor maintenance update with balance tweaks and bug fixes, not new content. No new content has been announced or shipped for the original game since the Full Spectrum update in October 2024. The developer's creative energy is now directed at Genome Guardian 2 and Cell Command, both of which are fully separate titles. The original Genome Guardian appears to have reached its complete state with Major Update 6 on October 14, 2024.
Evidence
Genome Guardian 2 launches into Early Access as a fully separate game, with the developer describing it as their magnum opus. No further content is announced for the original Genome Guardian.
news post · Mar 5, 2026 source development ending
high
Major Update 6: Full Spectrum ships all remaining turrets and perks, making 100% checklist completion officially possible for the first time. This is described as completing the full content roster.
news post · Oct 14, 2024 source content shipped
high

Media

Details

Developer
Publisher
Alpherior
Achievements
100
Platform
Windows
Controller
full support
Steam Deck
Playable
Players
Single-player

About this game

Dive into the microscopic world, radiating with bioluminescent life and unspeakable horrors. Genome Guardian is a deeply-complex shooter that's easy to pick up but hard to master. Research permanent upgrades to survive a variety of microbes across 6 game modes, each with multiple "depths".

Pair DNA nucleotides Adenine (rapidfire), Cytosine (precision), Guanine (spread), Thymine (explosive) to discover wild hybrid bioweapons!

  • Bomb + Shotgun combines explosives with spread to create Blast Shotgun!

  • Bomb + Bomb doubles down on explosive power to make Bazooka!

  • Blast Shotgun + Shotgun forms the all-powerful Flak Cannon!

  • 49 Turrets with unique strengths and functions

  • 96 Perks to mix and match that drastically change how you play

  • 75 Weapon & Turret Mods that can turn shots into sticky laser mines or bouncing fireballs

  • 64 Mutations alter the challenges you face each run

  • 20-minute Runs that can be continued in Endless Mode

  • 75 Bassy Electronic Tunes that adapt to the current mood & intensity

  • Cosmetics like spider legs and tank tread

  • Accessibility Settings for colourblindness, motion sickness, and even arachnophobia!

  • 100 Steam Achievements

  • Steam Trading Cards

  • Cloud Save

  • Plays great on Steam Deck!!!

Last evaluated Jun 20, 2026
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